反应详情

温度

25 °C

400 mg 7-Bromoquinazolin-4(3H)-one was dissolved in DMF and 720 mg of CsCO3 and 130 μL of methyliodide were added and the mixture stirred for 3 h at 25° C. Additional 50 μL methyliodide were added and stirred overnight at 25° C. The mixture was filtered off and the mother liquor diluted with DCM and extracted with water. The solvent was removed to yield 490 mg of 7-bromo-3-methylquinazolin-4(3H)-one as solid.

1. stirringstirred overnight at 25° C
2. filtrationThe mixture was filtered off
3. additionthe mother liquor diluted with DCM
4. extractionextracted with water
5. customThe solvent was removed