反应详情

温度

25 °C

Step 2 (=Reaction 2): 30 mg 1-(2-(Phenylethynyl)pyridin-3-yl)ethanone were suspended in 350 μL 1N sulfuric acid and 2.147 mg mercuric chloride and stirred for 30 min at 60° C. Then 1 mL of NaOH was added and the mixture stirred for additional 1 h at 25° C. Water was added and a neutral pH adjusted with NaHCO3 solution. The precipitate was filtered off and washed with water and dried to yield 30 mg 7-phenylquinolin-5-ol 6.1 as solid. Analysis: HPLC-MS: Rt=1.18 min (method D), M+H=240.

1. customStep 2 (=Reaction 2)
2. filtrationThe precipitate was filtered off
3. washwashed with water
4. customdried