Potassium Carbonate → 1-(4-(4-((2,5-Dichloropyrimidin-4-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethanone

Participants

Reaction Conditions

Reaction Steps

1-(4-(4-amino-3-methoxyphenyl)piperazin-1-yl)ethanone (150 mg) prepared in Preparation Example 1, 2,4,5-trichloropyrimidine (120 mg) and potassium carbonate (120 mg) were dissolved in dimethylformamide (2 ml), and stirred at 80° C. overnight. The dimethylformamide of the mixture was removed under reduced pressure and added with water to form a solid. The solid was filtered to obtain a target compound.

Provenance & Evidence