Potassium Carbonate → 1-(4-(4-((2,5-Dichloropyrimidin-4-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethanone

HRID 1496969Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:16])[CH3:15])[CH2:10][CH2:9]2)=[CH:4][C:3]=1[O:17][CH3:18].[Cl:19][C:20]1[N:25]=[C:24](Cl)[C:23]([Cl:27])=[CH:22][N:21]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:19][C:20]1[N:25]=[C:24]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[CH2:13][CH2:12][N:11]([C:14](=[O:16])[CH3:15])[CH2:10][CH2:9]3)=[CH:4][C:3]=2[O:17][CH3:18])[C:23]([Cl:27])=[CH:22][N:21]=1

Participants

Conditions

Temperature: 80 °C

Procedure

1-(4-(4-amino-3-methoxyphenyl)piperazin-1-yl)ethanone (150 mg) prepared in Preparation Example 1, 2,4,5-trichloropyrimidine (120 mg) and potassium carbonate (120 mg) were dissolved in dimethylformamide (2 ml), and stirred at 80° C. overnight. The dimethylformamide of the mixture was removed under reduced pressure and added with water to form a solid. The solid was filtered to obtain a target compound.

Workup

customThe dimethylformamide of the mixture was removed under reduced pressure
additionadded with water
customto form a solid
filtrationThe solid was filtered
customto obtain a target compound

Sources & evidence

ORD record: ord-2487e15a325a468196a026a096a660c0
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199944B2

Reaction notes

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