反应详情

温度

80 °C

1-(4-(4-amino-3-methoxyphenyl)piperazin-1-yl)ethanone (150 mg) prepared in Preparation Example 1, 2,4,5-trichloropyrimidine (120 mg) and potassium carbonate (120 mg) were dissolved in dimethylformamide (2 ml), and stirred at 80° C. overnight. The dimethylformamide of the mixture was removed under reduced pressure and added with water to form a solid. The solid was filtered to obtain a target compound.

1. customThe dimethylformamide of the mixture was removed under reduced pressure
2. additionadded with water
3. customto form a solid
4. filtrationThe solid was filtered
5. customto obtain a target compound