Hydrochloric Acid → HCID 178497975, compound

HRID 1496974Notes

Reaction equation

HRID 1496974 reaction equation
[OH:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=1.Cl.[CH3:12]O>O1CCOCC1>[OH:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:12])=[O:9])[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178524392HCID 178524392, compound

Product 1

HCID 178497975HCID 178497975, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 6-hydroxypicolinic acid (13.0 g, 93.5 mmol) in methanol (150 mL) at room temperature was added HCl in dioxane (4N, 10 mL). The resulting mixture was stirred at room temperature for 48 hours. The reaction mixture was concentrated to give methyl 6-hydroxypicolinate (13 g, 90%) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-04cc422e6e6d4708ba8c7b663f6af343
Source dataset
uspto-grants-2015_12
Patent number
US09199947B2

Reaction notes

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