反应详情

To a stirred solution of 5-hydroxynicotinic acid (10 g, 71.9 mmol) in MeOH (100 mL) was added sulfurous dichloride (1 mL) drop wise over 5 min. The resulting mixture was stirred at room temperature overnight. The resulted solution was added 100 mL of NaHCO3. The precipitate was filtrated and washed with MeOH for several cycles to give 8.5 g of A031-2 (75% yields), which was used for the nest step without further purification.

1. filtrationThe precipitate was filtrated
2. washwashed with MeOH for several cycles
3. customto give
4. custom8.5 g of A031-2 (75% yields), which
5. customwas used for the nest step without further purification