Cyclopentanol → 6-Chloro-2-cyclopentyloxy-4-phenyl-quinoline-3-carboxylic acid ethyl ester

HRID 1497063Notes

Reaction equation

HRID 1497063 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](Cl)=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])[CH3:2].[CH:24]1([OH:29])[CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:29][CH:24]2[CH2:28][CH2:27][CH2:26][CH2:25]2)=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 7298CyclopentanolHCID 1714247Ethyl 2,6-dichloro-4-phenylquinoline-3-carboxylate

Product 1

HCID 866829346-Chloro-2-cyclopentyloxy-4-phenyl-quinoline-3-carboxylic acid ethyl ester

Procedure

The title compound was prepared in analogy to example 11 step C from 2,6-dichloro-4-phenyl-quinoline-3-carboxylic acid ethyl ester (prepared as described in example 11 step B) and cyclopentanol. Colorless sticky liquid. (50 mg, 44%). LC-MS: 396 (M+H)+.

Sources & evidence

ORD record
ord-82e397ebeb4f4773ad145bddbd155330
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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