Lithium iodide → HCID 71556487, compound

HRID 1497097Notes

Reaction equation

HRID 1497097 reaction equation
C[O:2][C:3]([C:5]1[C:6]([CH:26]([CH3:28])[CH3:27])=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=1)=[CH:12][C:11]([Cl:25])=[CH:10][CH:9]=2)=[O:4].[I-].[Li+]>N1C=CC=CC=1>[Cl:25][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]=[C:6]([CH:26]([CH3:28])[CH3:27])[C:5]([C:3]([OH:4])=[O:2])=[C:14]2[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:23])([F:22])[F:24])[CH:16]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682956HCID 86682956, compound

Product 1

HCID 71556487HCID 71556487, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-2-isopropyl-4-(3-trifluoromethyl-phenyl)-quinoline-3-carboxylic acid methyl ester (50 mg, 0.12 mmol) and lithium iodide in pyridine. Off-white solid (19 mg, 39.35%). LC-MS: 392 (M−H)−.

Sources & evidence

ORD record
ord-cf793161245f4d4c8cdbc731f6f37773
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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