Lithium iodide → HCID 71556491, compound

HRID 1497106Notes

Reaction equation

HRID 1497106 reaction equation
C([O:3][C:4]([C:6]1[C:7]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])C.[Li+].[I-]>N1C=CC=CC=1>[Cl:22][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1)[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 86682960HCID 86682960, compound

Product 1

HCID 71556491HCID 71556491, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-4-phenyl-2-pyrrolidin-1-yl-quinoline-3-carboxylic acid ethyl ester (100 mg, 0.26 mmol) and LiI (351.4 mg, 2.63 mmol) in pyridine. Pale yellow solid (74 mg, 80%). LC-MS: 351 (M−H)−.

Sources & evidence

ORD record
ord-bb0574848f8a4778bf2aa10d54b8c21b
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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