Ethyl isobutyrylacetate → HCID 86682962, compound

HRID 1497109Notes

Reaction equation

HRID 1497109 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[CH:3]=1.[CH2:19]([O:21][C:22](=[O:29])[CH2:23][C:24](=O)[CH:25]([CH3:27])[CH3:26])[CH3:20]>CCO>[CH2:19]([O:21][C:22]([C:23]1[C:24]([CH:25]([CH3:27])[CH3:26])=[N:8][C:5]2[C:4]([C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][CH3:18])=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[O:29])[CH3:20]

Participants

4

Reactant 2

HCID 81583Ethyl isobutyrylacetateHCID 86682963HCID 86682963, compound

Product 1

HCID 86682962HCID 86682962, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 10 step B from 4-chloro-2-(2-methoxy-phenylethynyl)-phenylamine (200 mg, 0.78 mmol) and 4-methyl-3-oxo-pentanoic acid ethyl ester (0.2 ml, 1.16 mmol) in anhydrous EtOH (8 ml). Light green liquid. (100 mg, 32% yield). LC-MS (ESI): 398 (M+H)+.

Sources & evidence

ORD record
ord-f69d671206bb4535991252771461bbe1
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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