Trifluoroacetic acid → HCID 71556557, compound

HRID 1497120Notes

Reaction equation

C([O:5][C:6]([C:8]1[C:9]([N:25]([CH2:27][CH2:28][OH:29])[CH3:26])=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][C:14]([Cl:24])=[CH:13][CH:12]=2)=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[Cl:24][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([N:25]([CH2:27][CH2:28][OH:29])[CH3:26])[C:8]([C:6]([OH:7])=[O:5])=[C:17]2[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86682969HCID 86682969, compound

Product 1

HCID 71556557HCID 71556557, compound

Procedure

The title compound was prepared in analogy to example 42 step B from 6-chloro-2-[(2-hydroxy-ethyl)-methyl-amino]-4-phenyl-quinoline-3-carboxylic acid tert-butyl ester and TFA. Light yellow solid. MS (ESI): 355 (M−H)−.

Sources & evidence

ORD record: ord-ad234b7425b34207a31aef81c1b1a06e
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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