Diethylamine → HCID 86682972, compound

HRID 1497127Notes

Reaction equation

HRID 1497127 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](Cl)=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])[CH3:2].[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([N:26]([CH2:27][CH3:28])[CH2:24][CH3:25])=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 1714247Ethyl 2,6-dichloro-4-phenylquinoline-3-carboxylate

Product 1

HCID 86682972HCID 86682972, compound

Procedure

The title compound was prepared in analogy to example 37 step A from 2,6-dichloro-4-phenyl-quinoline-3-carboxylic acid ethyl ester (prepared as described in example 11 step B, 100 mg, 0.29 mmol) and diethyl-amine (0.06 ml, 0.58 mmol). Sticky liquid (70 mg, 63%). LC-MS: 383 (M+H)+.

Sources & evidence

ORD record
ord-ec90c1ec083a4255a1663200be16c2bb
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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