Lithium iodide → HCID 71556819, compound

HRID 1497156Notes

Reaction equation

C([O:3][C:4]([C:6]1[C:7]([CH:29]([CH3:31])[CH3:30])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][C:24]([F:27])([F:26])[F:25])=[CH:13][C:12]([Cl:28])=[CH:11][CH:10]=2)=[O:5])C.[I-].[Li+]>>[Cl:28][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:29]([CH3:30])[CH3:31])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][C:24]([F:26])([F:25])[F:27]

Participants

Reactant 2

HCID 66321Lithium iodide

HCID 86682994HCID 86682994, compound

Product 1

HCID 71556819HCID 71556819, compound

Procedure

The title compound was prepared in analogy to example 20 step D from 6-chloro-2-isopropyl-4-(2-trifluoromethoxy-benzyl)-quinoline-3-carboxylic acid ethyl ester (70 mg, 0.16 mmol) and lithium iodide. Off white solid (18 mg, 27%). LC-MS (ESI): 422 (M−H)−.

Sources & evidence

ORD record: ord-295f0b1cd69140328295765f417c358c
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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