2-Amino-5-chlorobenzophenone → N-(2-Benzoyl-4-chloro-phenyl)-malonamic acid methyl ester

HRID 1497166Notes

Reaction equation

HRID 1497166 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].Cl[C:18](=[O:24])[CH2:19][C:20]([O:22][CH3:23])=[O:21]>>[CH3:23][O:22][C:20](=[O:21])[CH2:19][C:18]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:10])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:24]

Participants

3

Reactant 2

HCID 128702-Amino-5-chlorobenzophenoneHCID 123460Methyl malonyl chloride

Product 1

HCID 11624106N-(2-Benzoyl-4-chloro-phenyl)-malonamic acid methyl ester

Procedure

The title compound was prepared in analogy to example 21 step A from (2-amino-5-chloro-phenyl)-phenyl-methanone and methyl 3-chloro-3-oxopropanoate. Off-white solid. MS (ESI): 330.1 (M−H)−.

Sources & evidence

ORD record
ord-871d20e95b5d450a888493a416e84cfb
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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