1,1,1-Trifluoro-2-propanol → HCID 86683012, compound

HRID 1497181Notes

Reaction equation

HRID 1497181 reaction equation
[C:1]([O:5][C:6]([C:8]1[C:9]([O:28]S(C(F)(F)F)(=O)=O)=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]([CH3:26])[CH3:25])[CH:19]=1)=[CH:15][C:14]([Cl:27])=[CH:13][CH:12]=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:36][C:37]([F:42])([F:41])[CH:38](O)[CH3:39]>>[C:1]([O:5][C:6]([C:8]1[C:9]([O:28][CH:38]([CH3:39])[C:37]([F:42])([F:41])[F:36])=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]([CH3:25])[CH3:26])[CH:19]=1)=[CH:15][C:14]([Cl:27])=[CH:13][CH:12]=2)=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 97741,1,1-Trifluoro-2-propanolHCID 86683008HCID 86683008, compound

Product 1

HCID 86683012HCID 86683012, compound

Procedure

The title compound was prepared in analogy to example 79 step A from 6-chloro-4-(3-isopropyl-phenyl)-2-trifluoromethanesulfonyloxy-quinoline-3-carboxylic acid tert-butyl ester (prepared as described in example 78 step C, 250 mg, 0.47 mmol) and 1,1,1-trifluoro-propan-2-ol (64.57 mg, 0.57 mmol). Off white solid (100 mg, 43%). LC-MS (ESI): 494 (M+H)+.

Sources & evidence

ORD record
ord-8bebb0af4e7c4f8cb6ff48332ee8767f
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

Loading…