1-Chloro-2-ethynylbenzene → HCID 86683013, compound

HRID 1497184Notes

Reaction equation

HRID 1497184 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([NH2:10])=[C:4](I)[CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]#[CH:20]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([NH2:10])=[C:4]([C:20]#[C:19][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[Cl:12])[CH:3]=1

Participants

3

Reactant 2

HCID 5859951-Chloro-2-ethynylbenzeneHCID 67187010HCID 67187010, compound

Product 1

HCID 86683013HCID 86683013, compound

Procedure

The title compound was prepared in analogy to example 10 step A from 4-chloro-2-iodo-6-methoxy-phenylamine (300 mg, 1.06 mmol) and 1-chloro-2-ethynyl-benzene (174 mg, 1.27 mmol). Brown solid (220 mg, 71%). LC-MS (ESI): 292 (M+H)+.

Sources & evidence

ORD record
ord-e30b23f268a143eab8ea4116089e1cdb
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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