Ethyl isobutyrylacetate → HCID 86683014, compound

HRID 1497185Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([NH2:10])=[C:4]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[CH:3]=1.[CH2:20]([O:22][C:23](=[O:30])[CH2:24][C:25](=O)[CH:26]([CH3:28])[CH3:27])[CH3:21]>>[CH2:20]([O:22][C:23]([C:24]1[C:25]([CH:26]([CH3:28])[CH3:27])=[N:10][C:5]2[C:4]([C:11]=1[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=2[O:8][CH3:9])=[O:30])[CH3:21]

Participants

Reactant 2

HCID 81583Ethyl isobutyrylacetate

HCID 86683013HCID 86683013, compound

Product 1

HCID 86683014HCID 86683014, compound

Procedure

The title compound was prepared in analogy to example 10 step B from 4-chloro-2-(2-chloro-phenylethynyl)-6-methoxy-phenylamine (200 mg, 0.68 mmol) and 4-methyl-3-oxo-pentanoic acid ethyl ester (0.166 ml, 1.03 mmol). Brown solid (45 mg, 15%). LC-MS (ESI): 432 (M+H)+.

Sources & evidence

ORD record: ord-7f3c7d9df0f04e8f9c95ff554dc82645
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

Loading…