Sodium Hydroxide → HCID 71555921, compound

HRID 1497192Notes

Reaction equation

HRID 1497192 reaction equation
C([O:3][C:4]([C:6]1[C:7]([N:29]([CH3:31])[CH3:30])=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23])=[CH:13][C:12]([Cl:24])=[CH:11][C:10]=2[C:25]([F:28])([F:27])[F:26])=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:24][C:12]1[CH:13]=[C:14]2[C:9](=[C:10]([C:25]([F:28])([F:26])[F:27])[CH:11]=1)[N:8]=[C:7]([N:29]([CH3:30])[CH3:31])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Cl:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86683018HCID 86683018, compound

Product 1

HCID 71555921HCID 71555921, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared in analogy to example 12 step B from a mixture of 6-chloro-4-(2-chloro-benzyl)-2-dimethylamino-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester (50 mg, 0.106 mmol) and 1N NaOH in ethanol. Pale yellow solid (22 mg, 47%). LC-MS (ESI): 441 (M−H)−.

Sources & evidence

ORD record
ord-067012e52fad416c9aebccc2d7807d68
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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