Ethyl 3-chloro-3-oxopropionate → N-[4-Chloro-2-(2-trifluoromethyl-phenylethynyl)-phenyl]-malonamic acid ethyl ester
Reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:20])([F:19])[F:18])[CH:3]=1.[CH2:21]([O:23][C:24](=[O:29])[CH2:25][C:26](Cl)=[O:27])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:29])[CH2:25][C:26]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([Cl:1])=[CH:3][C:4]=1[C:9]#[C:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]([F:18])([F:19])[F:20])=[O:27])[CH3:22]Participants
3
Procedure
The title compound was prepared in analogy to example 29 step A from 4-chloro-2-((2-(trifluoromethyl)phenyl)ethynyl)aniline (200 mg, 0.68 mmol) and chlorocarbonyl-acetic acid ethyl ester (128 μl, 1.01 mmol). Off white solid (213 mg, 77%). MS (ESI): 410 (M+H)+.
Sources & evidence
- ORD record
- ord-b29eec8c44bd4d9eaeaa8e917930f689
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199938B2
Reaction notes
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