HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-chloro-3-oxopropionate → N-[4-Chloro-2-(2-trifluoromethyl-phenylethynyl)-phenyl]-malonamic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-chloro-3-oxopropionate | HCID 118931 | — |
| Reactant | 4-Chloro-2-((2-(trifluoromethyl)phenyl)ethynyl)aniline | HCID 86683023 | — |
| Product | N-[4-Chloro-2-(2-trifluoromethyl-phenylethynyl)-phenyl]-malonamic acid ethyl ester | HCID 86683024 | — |
Reaction Steps
The title compound was prepared in analogy to example 29 step A from 4-chloro-2-((2-(trifluoromethyl)phenyl)ethynyl)aniline (200 mg, 0.68 mmol) and chlorocarbonyl-acetic acid ethyl ester (128 μl, 1.01 mmol). Off white solid (213 mg, 77%). MS (ESI): 410 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199938B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-b29eec8c44bd4d9eaeaa8e917930f689 |
| Source note | uspto-grants-2015_12 |