Piperidine → HCID 86683026, compound

HRID 1497203Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[C:7](OS(C)(=O)=O)=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]([F:26])([F:25])[F:24])=[CH:13][C:12]([Cl:27])=[CH:11][CH:10]=2)=[O:5])[CH3:2].[NH:33]1[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([N:33]2[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]2)=[N:8][C:9]2[C:14]([C:15]=1[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]([F:25])([F:24])[F:26])=[CH:13][C:12]([Cl:27])=[CH:11][CH:10]=2)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 8082Piperidine

HCID 86683027HCID 86683027, compound

Product 1

HCID 86683026HCID 86683026, compound

Procedure

The title compound was prepared in analogy to example 29 step D from crude 6-chloro-2-methanesulfonyloxy-4-(2-trifluoromethyl-benzyl)-quinoline-3-carboxylic acid ethyl ester (prepared in analogy to example 29 step C) and piperidine. Off white solid. MS (ESI): 477 (M+H)+.

Sources & evidence

ORD record: ord-31f0b581632240d09f76cf4c8a3b3220
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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