Piperidine → HCID 86683035, compound

HRID 1497212Notes

Reaction equation

HRID 1497212 reaction equation
[C:1]([O:5][C:6]([C:8]1[C:9](OS(C(F)(F)F)(=O)=O)=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1)=[CH:15][C:14]([Cl:25])=[CH:13][CH:12]=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>>[C:1]([O:5][C:6]([C:8]1[C:9]([N:34]2[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]2)=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1)=[CH:15][C:14]([Cl:25])=[CH:13][CH:12]=2)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 86683033HCID 86683033, compound

Product 1

HCID 86683035HCID 86683035, compound

Procedure

The title compound was prepared in analogy to example 92 step A from 6-chloro-4-(3-chloro-phenyl)-2-trifluoromethanesulfonyloxy-quinoline-3-carboxylic acid tert-butyl ester (prepared as described in example 91 step C, 150 mg, 0.29 mmol) and piperidine (0.057 ml, 0.58 mmol). Pale yellow solid (95 mg, 72%). LC-MS (ESI): 457 (M+H)+.

Sources & evidence

ORD record
ord-268f5594892140c886ba7298ea7c1a65
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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