Hydrochloric Acid → HCID 86683038, compound

HRID 1497215Notes

Reaction equation

HRID 1497215 reaction equation
C([O:5][C:6]([C:8]1[C:9]([N:26]([CH3:28])[CH3:27])=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1)=[CH:15][C:14]([Cl:25])=[CH:13][CH:12]=2)=[O:7])(C)(C)C.Cl>O1CCOCC1>[Cl:25][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([N:26]([CH3:27])[CH3:28])[C:8]([C:6]([OH:7])=[O:5])=[C:17]2[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86683037HCID 86683037, compound

Product 1

HCID 86683038HCID 86683038, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared in analogy to example 91 step E from 6-chloro-4-(3-chloro-phenyl)-2-dimethylamino-quinoline-3-carboxylic acid tert-butyl ester (70 mg, 0.17 mmol) and 4N HCl in dioxane. Off white solid (41 mg, 68%). LC-MS (ESI): 361 (M+H)+.

Sources & evidence

ORD record
ord-1f9be8f559164399bf0dba94a4557c6d
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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