1,1,1-Trifluoro-2-propanol → HCID 86683041, compound

HRID 1497218Notes

Reaction equation

HRID 1497218 reaction equation
[C:1]([O:5][C:6]([C:8]1[C:9]([O:26]S(C(F)(F)F)(=O)=O)=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1)=[CH:15][C:14]([Cl:25])=[CH:13][CH:12]=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:34][C:35]([F:40])([F:39])[CH:36](O)[CH3:37]>>[C:1]([O:5][C:6]([C:8]1[C:9]([O:26][CH:36]([CH3:37])[C:35]([F:40])([F:39])[F:34])=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1)=[CH:15][C:14]([Cl:25])=[CH:13][CH:12]=2)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 97741,1,1-Trifluoro-2-propanolHCID 86683033HCID 86683033, compound

Product 1

HCID 86683041HCID 86683041, compound

Procedure

The title compound was prepared in analogy to example 92 step A from 6-chloro-4-(3-chloro-phenyl)-2-trifluoromethanesulfonyloxy-quinoline-3-carboxylic acid tert-butyl ester (prepared as described in example 91 step C, 150 mg, 0.29 mmol) and 1,1,1-trifluoro-propan-2-ol (0.052 ml, 0.58 mmol). Sticky pale yellow liquid (70 mg, 50%). LC-MS (ESI): 486 (M+H)+.

Sources & evidence

ORD record
ord-9d52df2aae384339b8fd2d5ae228c1cd
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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