Diethylamine → Diethyl-[4-phenyl-3-(2H-tetrazol-5-yl)-6-trifluoromethyl-quinolin-2-yl]-amine

HRID 1497237Notes

Reaction equation

Cl[C:2]1[C:11]([C:12]2[NH:16][N:15]=[N:14][N:13]=2)=[C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]([F:26])([F:25])[F:24])[CH:8]=2)[N:3]=1.[CH2:27]([NH:29][CH2:30][CH3:31])[CH3:28]>>[CH2:27]([N:29]([CH2:30][CH3:31])[C:2]1[C:11]([C:12]2[N:16]=[N:15][NH:14][N:13]=2)=[C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]([F:24])([F:26])[F:25])[CH:8]=2)[N:3]=1)[CH3:28]

Participants

Reactant 2

HCID 8021Diethylamine

HCID 178506080HCID 178506080, compound

Product 1

HCID 86683057Diethyl-[4-phenyl-3-(2H-tetrazol-5-yl)-6-trifluoromethyl-quinolin-2-yl]-amine

Procedure

The title compound was prepared in analogy to example 102 step C from 2-chloro-4-phenyl-3-(1H-tetrazol-5-yl)-6-trifluoromethyl-quinoline (prepared as described in example 102 step B) and diethylamine. Light yellow solid. MS (ESI): 413.4 (M+H)+.

Sources & evidence

ORD record: ord-db713a5e210d4abda0b9fb113f07625a
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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