Piperidine → HCID 86683063, compound

HRID 1497247Notes

Reaction equation

Cl[C:2]1[C:11]([C:12]2[NH:16][N:15]=[N:14][N:13]=2)=[C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:9]2[C:4](=[CH:5][C:6]([F:24])=[C:7]([Cl:23])[CH:8]=2)[N:3]=1.[NH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[Cl:23][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[F:24])[N:3]=[C:2]([N:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1)[C:11]([C:12]1[N:16]=[N:15][NH:14][N:13]=1)=[C:10]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 8082Piperidine

HCID 178505399HCID 178505399, compound

Product 1

HCID 86683063HCID 86683063, compound

Procedure

The title compound was prepared in analogy to example 102 step C from 2,6-dichloro-7-fluoro-4-phenyl-3-(1H-tetrazol-5-yl)-quinoline and piperidine. Off-white solid. MS (ESI): 409.5 (M+H)+.

Sources & evidence

ORD record: ord-ea691289f0f0479897fbd11fc78467ca
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199938B2

Reaction notes

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