(2-Amino-5-chlorophenyl)(3-chlorophenyl)methanone → 6-Chloro-4-(3-chloro-phenyl)-2-cyclobutyl-quinoline-3-carbonitrile

HRID 1497252Notes

Reaction equation

HRID 1497252 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=O.[CH:18]1([C:22](=O)[CH2:23][C:24]#[N:25])[CH2:21][CH2:20][CH2:19]1>>[Cl:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:22]([CH:18]1[CH2:21][CH2:20][CH2:19]1)[C:23]([C:24]#[N:25])=[C:9]2[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1

Participants

3

Reactant 2

HCID 5231029(2-Amino-5-chlorophenyl)(3-chlorophenyl)methanoneHCID 138611153-Cyclobutyl-3-oxopropanenitrile

Product 1

HCID 866830686-Chloro-4-(3-chloro-phenyl)-2-cyclobutyl-quinoline-3-carbonitrile

Procedure

The title compound was prepared in analogy to example 101 step B from (2-amino-5-chloro-phenyl)-(3-chloro-phenyl)-methanone (prepared as described in example 91 step A) and 3-cyclobutyl-3-oxo-propionitrile (prepared as described in example 104 step A). Yellow foam. MS (ESI): 353.3 (M+H)+.

Sources & evidence

ORD record
ord-448ba215560c4c1cbba3a977b60dc6b0
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

Loading…