(2-Amino-5-(trifluoromethyl)phenyl)(phenyl)methanone → 2-(1-Ethyl-propyl)-4-phenyl-6-trifluoromethyl-quinoline-3-carbonitrile

HRID 1497253Notes

Reaction equation

HRID 1497253 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O.[CH2:20]([CH:22]([CH2:28][CH3:29])[C:23](=O)[CH2:24][C:25]#[N:26])[CH3:21]>>[CH2:20]([CH:22]([C:23]1[C:24]([C:25]#[N:26])=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:3]2[C:2](=[CH:7][CH:6]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:4]=2)[N:1]=1)[CH2:28][CH3:29])[CH3:21]

Participants

3

Reactant 2

HCID 13014169(2-Amino-5-(trifluoromethyl)phenyl)(phenyl)methanoneHCID 235057484-Ethyl-3-oxohexanenitrile

Product 1

HCID 866830692-(1-Ethyl-propyl)-4-phenyl-6-trifluoromethyl-quinoline-3-carbonitrile

Procedure

The title compound was prepared in analogy to example 101 step B from (2-amino-5-trifluoromethyl-phenyl)-phenyl-methanone and 4-ethyl-3-oxo-hexanenitrile (prepared as described in example 101 step A). Off-white solid. MS (ESI): 369.4 (M+H)+.

Sources & evidence

ORD record
ord-2174e0bae04a4fc7b2dfcda6ebaa7706
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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