3,3-Difluoroazetidine hydrochloride → HCID 86683076, compound

HRID 1497260Notes

Reaction equation

HRID 1497260 reaction equation
Cl[C:2]1[C:11]([C:12]2[NH:16][N:15]=[N:14][N:13]=2)=[C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:9]2[C:4](=[CH:5][C:6]([F:24])=[C:7]([Cl:23])[CH:8]=2)[N:3]=1.Cl.[F:26][C:27]1([F:31])[CH2:30][NH:29][CH2:28]1>C(N(CC)CC)C>[Cl:23][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[F:24])[N:3]=[C:2]([N:29]1[CH2:30][C:27]([F:31])([F:26])[CH2:28]1)[C:11]([C:12]1[N:13]=[N:14][NH:15][N:16]=1)=[C:10]2[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 27582473,3-Difluoroazetidine hydrochlorideHCID 178505399HCID 178505399, compound

Product 1

HCID 86683076HCID 86683076, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared in analogy to example 102 step C from 2,6-dichloro-7-fluoro-4-phenyl-3-(1H-tetrazol-5-yl)-quinoline (prepared as described in example 107 step B), 3,3-difluoroazetidine hydrochloride and triethylamine. Light brown solid. MS (ESI): 417.4 (M+H)+.

Sources & evidence

ORD record
ord-71a2a3bd23154a6ca6d961790ed7a509
Source dataset
uspto-grants-2015_12
Patent number
US09199938B2

Reaction notes

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