反应详情

To a 0° C. solution of 2-methoxyisonicotinic acid (V1) (490 mg, 3.20 mmol) in anhydrous THF (15 ml) was added dropwise lithium aluminum hydride (3.20 ml, 6.40 mmol) (2.0 N in Et2O), and the mixture was stirred at room temperature for overnight. The reaction mixture was cooled back to 0° C. 0.28 ml H2O, 0.21 ml of 20% NaOH solution, 0.98 ml H2O were added drop-wise sequentially and stirred for 1 h. The solid was filtered and wash with THF and the filtrate was concentrated to give (2-methoxypyridin-4-yl)methanol (V2) as a clear oil. It was carried over to next step without further purifications. ES-MS [M+1]1: 140.1.

1. temperatureThe reaction mixture was cooled back to 0° C
2. stirringstirred for 1 h
3. filtrationThe solid was filtered
4. washwash with THF
5. concentrationthe filtrate was concentrated