1-Bromo-3-methoxypropane → (rac)-(3aSR,6aRS)-3-(3-Methoxy-propyl)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH:12]2[CH2:13][CH2:14][CH2:15][CH:11]2[NH:10][C:9]1=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:18][CH2:19][CH2:20][O:21][CH3:22]>>[C:1]([O:5][C:6]([N:8]1[CH:12]2[CH2:13][CH2:14][CH2:15][CH:11]2[N:10]([CH2:18][CH2:19][CH2:20][O:21][CH3:22])[C:9]1=[O:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
The title compound was prepared in accordance with the general method of example 1, step 2 starting from (rac)-(3aSR,6aRS)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl ester (Example 1, step 1) and using 1-bromo-3-methoxypropane instead of iodoethane to yield the desired product as a light yellow oil which was directly used in the next step without further characterisation.
Sources & evidence
- ORD record
- ord-51348cedf0304f7289c41a6ecd8c2cc1
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199971B2
Reaction notes
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