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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1497354Generated: November 2, 2026

1-Bromo-3-methoxypropane → (rac)-(3aSR,6aRS)-3-(3-Methoxy-propyl)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/1497354

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-methoxypropaneHCID 524551—
Reactant(3aSR, 6aRS)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl esterHCID 67437675—
Product(rac)-(3aSR,6aRS)-3-(3-Methoxy-propyl)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl esterHCID 90039158—

Reaction Steps

The title compound was prepared in accordance with the general method of example 1, step 2 starting from (rac)-(3aSR,6aRS)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl ester (Example 1, step 1) and using 1-bromo-3-methoxypropane instead of iodoethane to yield the desired product as a light yellow oil which was directly used in the next step without further characterisation.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09199971B2
Source datasetuspto-grants-2015_12
ORD IDord-51348cedf0304f7289c41a6ecd8c2cc1
Source noteuspto-grants-2015_12