Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1497371Generated: November 2, 2026

4-(benzyloxy)-1-(2,3-dimethyl-2H-indazol-5-yl)pyridin-2(1H)-one → 1-(2,3-dimethyl-2H-indazol-5-yl)-4-hydroxypyridin-2(1H)-one

https://huagongshe.com/reaction/1497371

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(benzyloxy)-1-(2,3-dimethyl-2H-indazol-5-yl)pyridin-2(1H)-oneHCID 117816803—
CatalystHCID 178418390HCID 178418390—
SolventEthanolHCID 702—
Product1-(2,3-dimethyl-2H-indazol-5-yl)-4-hydroxypyridin-2(1H)-oneHCID 11779867078.2%

Reaction Steps

To a solution of 4-(benzyloxy)-1-(2,3-dimethyl-2H-indazol-5-yl)pyridin-2(1H)-one (1.8 g) in ethanol (40 ml) was added 10% palladium carbon (0.56 g), and the mixture was stirred under a hydrogen atmosphere at room temperature for 3 hr. The insoluble material was filtered off, and the obtained filtrate was concentrated under reduced pressure to give the title compound (1.04 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09199963B2
Source datasetuspto-grants-2015_12
ORD IDord-78e4a90666124d03bdce7a2a7f3f1a55
Source noteuspto-grants-2015_12