Dichloromethane → 4'-Isopropyl-5-methyl-biphenyl-2-carboxylic acid (4-piperazin-1-yl-phenyl)-amide

HRID 149753Notes

Reaction equation

HRID 149753 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[c:23]3[c:24](-[c:30]4[cH:31][cH:32][c:33]([CH:36]([CH3:37])[CH3:38])[cH:34][cH:35]4)[cH:25][c:26]([CH3:29])[cH:27][cH:28]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:46][CH2:47][Cl:48].[OH:39][C:40]([C:41]([F:42])([F:43])[F:44])=[O:45]>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[c:23]3[c:24](-[c:30]4[cH:31][cH:32][c:33]([CH:36]([CH3:37])[CH3:38])[cH:34][cH:35]4)[cH:25][c:26]([CH3:29])[cH:27][cH:28]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 540547824-{4-[(4'-Isopropyl-5-methyl-biphenyl-2-carbonyl)-amino]-phenyl}piperazine-1-carboxylic Acid Tert-Butyl Ester

Product 1

HCID 537730414'-Isopropyl-5-methyl-biphenyl-2-carboxylic acid (4-piperazin-1-yl-phenyl)-amide

Sources & evidence

ORD record
ord-a0ec5def941c4b4c8c91cd37c35af1f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…