Hydrazine hydrate (1:1) → 5-Bromo-2-hydrazinopyridine
Reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](Cl)=[N:6][CH:7]=1.O.[NH2:10][NH2:11]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:10][NH2:11])=[N:6][CH:7]=1Participants
3
Procedure
A mixture of 5-bromo-2-chloropyridine (11.5 g, 60 mmol) and hydrazine hydrate (100 mL) was refluxed under Argon for 2 h. The mixture was cooled to room temperature, filtered and the solids were washed with water (50 mL×3), dried to give the title compound (8.30 g, 74.4% yield) as yellow solids. MS: m/z 188.0 [M+H+].
Workup
- temperaturewas refluxed under Argon for 2 h
- filtrationfiltered
- washthe solids were washed with water (50 mL×3)
- customdried
Sources & evidence
- ORD record
- ord-fa7a94d7da1141f79ef3556788e1a771
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199983B2
Reaction notes
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