Hydrazine hydrate (1:1) → HCID 20300086, compound

HRID 1497576Notes

Reaction equation

HRID 1497576 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:4][N:3]=1.O.[NH2:17][NH2:18]>>[NH:17]([C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:4][N:3]=1)[NH2:18]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 121945632-Chloro-5-(4-methoxyphenyl)pyridine

Product 1

HCID 20300086HCID 20300086, compoundYield 78%

Conditions

Temperature
100 °C

Procedure

A round-bottom flask was charged with 2-chloro-5-(4-methoxyphenyl)pyridine (260 mg, 1.19 mmol) and hydrazine hydrate (4 mL) at room temperature. The reaction mixture was heated at 100° C. for 48 h. It was cooled to room temperature, then was kept in a refrigerator for 3 h. The precipitate was filtered, washed with cold water, and dried to give the title compound as gray solids (200 mg, 78.0% yield). MS: m/z 216.1 [M+H+].

Workup

  1. temperatureIt was cooled to room temperature
  2. filtrationThe precipitate was filtered
  3. washwashed with cold water
  4. customdried

Sources & evidence

ORD record
ord-4c193cd1b75c421cb2092bed208f8b69
Source dataset
uspto-grants-2015_12
Patent number
US09199983B2

Reaction notes

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