反应详情

温度

100 °C

A round-bottom flask was charged with 2-chloro-5-(4-methoxyphenyl)pyridine (260 mg, 1.19 mmol) and hydrazine hydrate (4 mL) at room temperature. The reaction mixture was heated at 100° C. for 48 h. It was cooled to room temperature, then was kept in a refrigerator for 3 h. The precipitate was filtered, washed with cold water, and dried to give the title compound as gray solids (200 mg, 78.0% yield). MS: m/z 216.1 [M+H+].

1. temperatureIt was cooled to room temperature
2. filtrationThe precipitate was filtered
3. washwashed with cold water
4. customdried