HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 67599708, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 4-Chloro-o-anisic acid | HCID 93682 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 20300086 | HCID 20300086 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67599708 | HCID 67599708 | 81.2% |
Reaction Steps
A solution of 2-hydrazinyl-5-(4-methoxyphenyl)pyridine (200 mg, 0.93 mmol), 4-chloro-2-methoxybenzoic acid (210 mg, 1.12 mmol), BOP (500 mg, 1.12 mmol) and NMM (330 mg, 3.27 mmol) in DCM (9 mL) was stirred at room temperature under Nitrogen overnight. The resulting mixture was filtered, and the solid was washed with DCM, dried to give the title compound as white solids (290 mg, 81.2% yield), which was used for the next reaction without further purification. MS: m/z 384.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199983B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-da6d6b1c95ce4075a385e156830c22b4 |
| Source note | uspto-grants-2015_12 |