反应详情

A solution of 2-hydrazinyl-5-(4-methoxyphenyl)pyridine (200 mg, 0.93 mmol), 4-chloro-2-methoxybenzoic acid (210 mg, 1.12 mmol), BOP (500 mg, 1.12 mmol) and NMM (330 mg, 3.27 mmol) in DCM (9 mL) was stirred at room temperature under Nitrogen overnight. The resulting mixture was filtered, and the solid was washed with DCM, dried to give the title compound as white solids (290 mg, 81.2% yield), which was used for the next reaction without further purification. MS: m/z 384.2 [M+H+].

1. filtrationThe resulting mixture was filtered
2. washthe solid was washed with DCM
3. customdried