反应详情

To a solution of piperidine-4-carboxamide (2 g, 15.6 mmol) in acetonitrile (30 mL), tert-butyldicarbonate (4.4 g, 20.2 mmol, 1.3 eq) and DMAP (190 mg, 1.56 mmol, 0.1 eq) were added and the mixture was stirred at r.t. overnight. It was then concentrated under reduced pressure, taken up with DCM and washed with saturated aqueous NaHCO3, saturated aqueous NH4Cl, brine and water. The organic phase was dried over Na2SO4 and evaporated to dryness. The residue was triturated with diethyl ether and the white solid was filtered and dried to give 2.65 g (74%) of the title product.

1. concentrationIt was then concentrated under reduced pressure
2. washwashed with saturated aqueous NaHCO3, saturated aqueous NH4Cl, brine and water
3. dry with materialThe organic phase was dried over Na2SO4
4. customevaporated to dryness
5. customThe residue was triturated with diethyl ether
6. filtrationthe white solid was filtered
7. customdried