3-Dimethylamino-2-(3-fluoro-pyridine-2-carbonyl)-acrylic acid ethyl ester → 2-(3-Chloro-pyrazine-2-carbonyl)-3-dimethylamino-acrylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]([C:8]1[C:13]([Cl:14])=[N:12][CH:11]=[CH:10][N:9]=1)=[O:7])[CH3:2].C(OC(=O)C(C(C1C(F)=CC=CN=1)=O)=[CH:21][N:22]([CH3:24])[CH3:23])C>>[CH2:1]([O:3][C:4](=[O:15])[C:5]([C:6]([C:8]1[C:13]([Cl:14])=[N:12][CH:11]=[CH:10][N:9]=1)=[O:7])=[CH:21][N:22]([CH3:24])[CH3:23])[CH3:2]Participants
3
Procedure
2-(3-Chloro-pyrazine-2-carbonyl)-3-dimethylamino-acrylic acid ethyl ester (13) (1.2 g, crude) was synthesized as a sticky liquid from 1 g of 3-(3-chloro-pyrazin-2-yl)-3-oxo-propionic acid ethyl ester (12) following the procedure described for 3-dimethylamino-2-(3-fluoro-pyridine-2-carbonyl)-acrylic acid ethyl ester (4).
Sources & evidence
- ORD record
- ord-0e57d51c3bbd47b5a28a0ec5038cad58
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199987B2
Reaction notes
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