HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Dimethylamino-2-(3-fluoro-pyridine-2-carbonyl)-acrylic acid ethyl ester → 2-(3-Chloro-pyrazine-2-carbonyl)-3-dimethylamino-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Dimethylamino-2-(3-fluoro-pyridine-2-carbonyl)-acrylic acid ethyl ester | HCID 86725434 | — |
| Reactant | Ethyl 3-chloro-beta-oxo-2-pyrazinepropanoate | HCID 86725436 | — |
| Product | 2-(3-Chloro-pyrazine-2-carbonyl)-3-dimethylamino-acrylic acid ethyl ester | HCID 86725437 | — |
Reaction Steps
2-(3-Chloro-pyrazine-2-carbonyl)-3-dimethylamino-acrylic acid ethyl ester (13) (1.2 g, crude) was synthesized as a sticky liquid from 1 g of 3-(3-chloro-pyrazin-2-yl)-3-oxo-propionic acid ethyl ester (12) following the procedure described for 3-dimethylamino-2-(3-fluoro-pyridine-2-carbonyl)-acrylic acid ethyl ester (4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199987B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-0e57d51c3bbd47b5a28a0ec5038cad58 |
| Source note | uspto-grants-2015_12 |