HCID 123300953, compound → HCID 117600148, compound

HRID 1497702Notes

Reaction equation

HRID 1497702 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]([N:16]([CH3:23])S(C(C)(C)C)=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CCOC(C)=O.Cl>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([CH:9]([NH:16][CH3:23])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:4]=1

Participants

3

Reactant 1

HCID 123300953HCID 123300953, compound

Product 1

HCID 117600148HCID 117600148, compound

Reagents, catalysts & solvents 1

HCID 21866389Hydrogen chloride-ethyl acetateSolvent

Procedure

To a solution of 2-Methyl-propane-2-sulfinic acid [(2-amino-5-bromo-phenyl)-phenyl-methyl]-methyl-amide (60 g, 152 mmol) in EtOAc/HCl (600 mL) is stirred at r.t. for 2 h. The mixture is concentrated and NaHCO3 is added to brought the PH>7, extracted with EtOAc. The organic layer is concentrated to give product. This is used in the next step without further purification.

Workup

  1. concentrationThe mixture is concentrated
  2. additionNaHCO3 is added
  3. extractionextracted with EtOAc
  4. concentrationThe organic layer is concentrated
  5. customto give product
  6. customThis is used in the next step without further purification

Sources & evidence

ORD record
ord-536f22f67a7d4b77a4f07ca50a8e9e29
Source dataset
uspto-grants-2015_12
Patent number
US09199988B2

Reaction notes

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