N-bromobutanimide → HCID 117600059, compound

HRID 1497745Notes

Reaction equation

HRID 1497745 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[N:6]([CH3:14])[C:7](=[O:13])[NH:8]2.C1C(=O)N([Br:28])C(=O)C1>C(Cl)Cl>[Br:28][C:12]1[C:3]([O:2][CH3:1])=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:13])[N:6]([CH3:14])[CH:5]2[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 117600835HCID 117600835, compound

Product 1

HCID 117600059HCID 117600059, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 5-Methoxy-3-methyl-4-phenyl-3,4-dihydro-1H-quinazolin-2-one (1.38 g, 0.005 mol) and NBS (0.82 g, 0.0046 mol) in DCM (150 mL) is stirred at r.t. for 4 h. The mixture is extracted with DCM from water and purified by column chromatography on silica gel using an ethylacetate and petrol ether gradient to give the desired product.

Workup

  1. extractionThe mixture is extracted with DCM from water
  2. custompurified by column chromatography on silica gel using an ethylacetate and petrol ether gradient

Sources & evidence

ORD record
ord-7c0259066ccf444087cdbd2dc429cd16
Source dataset
uspto-grants-2015_12
Patent number
US09199988B2

Reaction notes

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