N-bromobutanimide → HCID 117600059, compound

Participants

Reaction Steps

A mixture of 5-Methoxy-3-methyl-4-phenyl-3,4-dihydro-1H-quinazolin-2-one (1.38 g, 0.005 mol) and NBS (0.82 g, 0.0046 mol) in DCM (150 mL) is stirred at r.t. for 4 h. The mixture is extracted with DCM from water and purified by column chromatography on silica gel using an ethylacetate and petrol ether gradient to give the desired product.

Provenance & Evidence