HRID1497775

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6323

Methyl bromide

CH3Br

结构：Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)CCCN(C)C)nc2c1-c1cccc(C(F)(F)F)c1

HCID73051431

未命名化合物

PRODUCTS

生成物

结构：Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)CCC[N+](C)(C)C)nc2c1-c1cccc(C(F)(F)F)c1.[Br-]

HCID73051751

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from N-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-4-dimethylamino-butyramide (Ex. 16, 25 mg, 0.044 mmol) and MeBr (ca. 30% in EtOH, 0.15 mL) using a similar method to that employed for Example 15 (30 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3d5aea3d1e6469e9c7e0edb73d6af77
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09199984B2
来源说明: uspto-grants-2015_12

反应 SMILES

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[C:15]([CH3:42])=[C:16]([C:32]4[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=4)[C:17]4[N:18]([N:20]=[C:21]([NH:23][C:24](=[O:31])[CH2:25][CH2:26][CH2:27][N:28]([CH3:30])[CH3:29])[N:22]=4)[CH:19]=3)=[CH:12][CH:11]=[N:10]2)=[CH:5][CH:4]=1)#[N:2].[CH3:43][Br:44]>>[Br-:44].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([C:14]3[C:15]([CH3:42])=[C:16]([C:32]4[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:39])([F:40])[F:41])[CH:33]=4)[C:17]4[N:18]([N:20]=[C:21]([NH:23][C:24]([CH2:25][CH2:26][CH2:27][N+:28]([CH3:43])([CH3:30])[CH3:29])=[O:31])[N:22]=4)[CH:19]=3)=[CH:12][CH:11]=[N:10]2)=[CH:7][CH:8]=1)#[N:2]