Methyl Bromide → {3-[6-[2-(4-Cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylcarbamoyl]-propyl}-trimethyl-ammonium bromide
Reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[C:15]([CH3:42])=[C:16]([C:32]4[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=4)[C:17]4[N:18]([N:20]=[C:21]([NH:23][C:24](=[O:31])[CH2:25][CH2:26][CH2:27][N:28]([CH3:30])[CH3:29])[N:22]=4)[CH:19]=3)=[CH:12][CH:11]=[N:10]2)=[CH:5][CH:4]=1)#[N:2].[CH3:43][Br:44]>>[Br-:44].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([C:14]3[C:15]([CH3:42])=[C:16]([C:32]4[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:39])([F:40])[F:41])[CH:33]=4)[C:17]4[N:18]([N:20]=[C:21]([NH:23][C:24]([CH2:25][CH2:26][CH2:27][N+:28]([CH3:43])([CH3:30])[CH3:29])=[O:31])[N:22]=4)[CH:19]=3)=[CH:12][CH:11]=[N:10]2)=[CH:7][CH:8]=1)#[N:2]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared from N-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-4-dimethylamino-butyramide (Ex. 16, 25 mg, 0.044 mmol) and MeBr (ca. 30% in EtOH, 0.15 mL) using a similar method to that employed for Example 15 (30 mg).
Sources & evidence
- ORD record
- ord-b3d5aea3d1e6469e9c7e0edb73d6af77
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199984B2
Reaction notes
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