6-Bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine → 6-Bromo-2-chloro-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

HRID 1497808Notes

Reaction equation

HRID 1497808 reaction equation
[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[C:5]2[N:6]([N:8]=[C:9](N)[N:10]=2)[CH:7]=1.BrC1C(C)=C(C2C=CC=C(C(F)(F)F)C=2)C([Cl:30])=NC=1>>[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[C:5]2[N:6]([N:8]=[C:9]([Cl:30])[N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 867080876-Bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamineHCID 867081005-Bromo-2-chloro-4-methyl-3-(3-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 867081156-Bromo-2-chloro-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

Procedure

The title compound was prepared from 6-bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (Int. 2, 356 mg, 0.959 mmol) using a similar method to that employed in Intermediate 14 (130 mg).

Sources & evidence

ORD record
ord-3c4588faab254683b3891d05d046baad
Source dataset
uspto-grants-2015_12
Patent number
US09199984B2

Reaction notes

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