反应详情

To a solution of 4-{3-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-ureido}-piperidine-1-carboxylic acid tert-butyl ester (Int. 32, 95 mg, 0.14 mmol) in DCM (2 mL) was added TFA (1 mL) and the solution was stirred at RT for 1 hr, then toluene (10 mL) was added and the reaction mixture concentrated in vacuo. The reaction mixture was partitioned between DCM (15 ml) and aqueous 2 M Na2CO3, and the organic extract was dried (Na2SO4), filtered and concentrated in vacuo to give the title compound as a white solid (61 mg).

1. concentrationthe reaction mixture concentrated in vacuo
2. customThe reaction mixture was partitioned between DCM (15 ml) and aqueous 2 M Na2CO3
3. extractionthe organic extract
4. dry with materialwas dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo