HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 7-(1-(Tert-butoxycarbonyl)piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Ethyl 7-(1-(tert-butoxycarbonyl)piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxylate | HCID 71281180 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 7-(1-(Tert-butoxycarbonyl)piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxylic acid | HCID 71280885 | — |
Reaction Steps
To a stirring suspension of ethyl 7-(1-(tert-butoxycarbonyl)piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxylate (90) (84 mg, 0.23 mmol) in THF:MeOH:H2O (3:2:1, 1 mL) was added 6N LiOH (0.13 mL). The reaction was stirred at room temperature for 2.5 hours then neutralized with NH4Cl and concentrated to afford 7-(1-(tert-butoxycarbonyl)piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxylic acid (91) which was immediately used without purification. MS (m/z) 346.1 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199981B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-7bb9c06ce9094c48a2b84f68f7cc8b60 |
| Source note | uspto-grants-2015_12 |