HRID1497888

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

HCID25517

未命名化合物

结构：CCOC(=O)c1cnc2cc(C3CCN(C(=O)OC(C)(C)C)CC3)ccn12

HCID71281180

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(c2ccn3c(C(=O)O)cnc3c2)CC1

HCID71280885

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21892291

未命名化合物

PROCEDURE

实验过程

To a stirring suspension of ethyl 7-(1-(tert-butoxycarbonyl)piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxylate (90) (84 mg, 0.23 mmol) in THF:MeOH:H2O (3:2:1, 1 mL) was added 6N LiOH (0.13 mL). The reaction was stirred at room temperature for 2.5 hours then neutralized with NH4Cl and concentrated to afford 7-(1-(tert-butoxycarbonyl)piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxylic acid (91) which was immediately used without purification. MS (m/z) 346.1 (M+1)+.

WORKUP

后处理

concentrationconcentrated