Triethylamine → 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N-methylacetamide

HRID 1498337Notes

Reaction equation

HRID 1498337 reaction equation
Cl.[CH:2]([N:5]1[C:9]([C:10]2[N:19]=[C:18]3[N:12]([CH2:13][CH2:14][O:15][C:16]4[CH:23]=[C:22]([CH:24]5[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]5)[CH:21]=[CH:20][C:17]=43)[CH:11]=2)=[N:8][C:7]([CH3:30])=[N:6]1)([CH3:4])[CH3:3].C(N(CC)CC)C.Cl[CH2:39][C:40]([NH:42][CH3:43])=[O:41]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH:2]([N:5]1[C:9]([C:10]2[N:19]=[C:18]3[C:17]4[CH:20]=[CH:21][C:22]([CH:24]5[CH2:29][CH2:28][N:27]([CH2:39][C:40]([NH:42][CH3:43])=[O:41])[CH2:26][CH2:25]5)=[CH:23][C:16]=4[O:15][CH2:14][CH2:13][N:12]3[CH:11]=2)=[N:8][C:7]([CH3:30])=[N:6]1)([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 667732-chloro-N-methylacetamideHCID 67050639HCID 67050639, compound

Product 1

HCID 683553782-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N-methylacetamideYield 14.3%

Reagents, catalysts & solvents 1

HCID 67553Tetrabutylammonium IodideCatalyst

Procedure

To a suspension of 2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-8-piperidin-4-yl-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene hydrochloride (150 mg, 0.35 mmol) was added triethylamine (107 μL, 0.77 mmol) followed by 2-chloro-N-methyl-acetamide (41 mg, 0.38 mmol). The resultant mixture was stirred overnight before the addition of tetrabutylammonium iodide (13 mg, 0.04 mmol) and the reaction stirred for 24 hours. The mixture was washed with water then extracted with 10% MeOH in DCM (×5). The combined organic layers were dried (MgSO4), concentrated in vacuo and purified by flash column chromatography (SiO2, gradient 0-10% MeOH in DCM) twice to afford 275 (23 mg, 0.05 mmol, 14%). LCMS: RT=2.63 min, [M+H]+=464. 1H NMR δ (ppm) (CDCl3): 8.42 (1 H, d, J=8.30 Hz), 7.59 (1 H, s), 7.00 (1 H, dd, J=8.35, 1.83 Hz), 6.88 (1 H, d, J=1.79 Hz), 5.91-5.81 (1 H, m), 4.48-4.44 (2 H, m), 4.42-4.36 (2 H, m), 3.13-2.91 (4 H, m), 2.85 (3 H, d, J=4.98 Hz), 2.56-2.48 (1 H, m), 2.39 (3 H, s), 2.33 (2 H, s), 1.87 (2 H, s), 1.78 (2 H, s), 1.54 (6 H, d, J=6.65 Hz). NH not observed.

Workup

  1. washThe mixture was washed with water
  2. extractionthen extracted with 10% MeOH in DCM (×5)
  3. dry with materialThe combined organic layers were dried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. custompurified by flash column chromatography (SiO2, gradient 0-10% MeOH in DCM) twice

Sources & evidence

ORD record
ord-91929e542ac646d48f04f5b4011c8173
Source dataset
uspto-grants-2015_12
Patent number
US09198918B2

Reaction notes

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